Creating Cheesy Loaded Meatloaf Casserole with Vegetables is simple if you follow these clear steps:

1. Preheat the Oven: Preheat your oven to 350°F (175°C).
2. Prepare the Meat Mixture: In a large bowl, combine ground beef, breadcrumbs, egg, milk, garlic powder, onion powder, salt, and pepper. Mix until well combined.
3. Incorporate Vegetables: Gently fold in the mixed vegetables until evenly distributed throughout the meat mixture.
4. Add Cheese: Mix in 1 cup of shredded cheddar cheese to the meat mixture for a cheesy flavor.
5. Transfer to Casserole Dish: Grease a 9×13-inch casserole dish. Transfer the meat mixture into the dish and press it down evenly.
6. Add Topping: If desired, spread barbecue sauce over the top of the meatloaf for added flavor. Then, sprinkle additional cheese over the top.
7. Bake: Cover with aluminum foil and place the casserole in the preheated oven. Bake for about 30 minutes. After 30 minutes, remove the foil and continue baking for another 20 minutes, or until the cheese is bubbly and the meatloaf is cooked through.
8. Check for Doneness: Use a meat thermometer to ensure the internal temperature reaches 160°F (70°C).
9. Garnish: Once out of the oven, let the casserole sit for a few minutes. Garnish with fresh herbs like parsley or chives before serving.

These straightforward steps will guide you through crafting this delightful casserole without any hassle.